Inversion Report: HsInv0713

Human Polymorphic Inversion DataBase

Inversion Report: HsInv0713

General information

Accession	HsInv0713	Region of the inversion	chr8:6909899-12617968
Status	Predicted	Prediction type	Simple
Estimated Inversion Size	4,695,488 bp	Supporting predictions	3
Inverted allele frequency	ND	Mechanism of origin	ND
Functional effect	Intergenic breakpoints	Breakpoint 1	chr8:6909899-8134378
Ancestral orientation	NA	Breakpoint 2	chr8:11817284-12617968

- Region map

+ Predictions

+ Validation and genotyping

+ Frequency

+ Breakpoints

Breakpoint 1	chr8:6909899-8134378	Breakpoint 2	chr8:11817284-12617968
Definition method	Default informatic definition
Mechanism of origin	ND

Flexibility

5.84

GC content

0.14

Stability

0.85

Sequence features
Segmental duplications:

Position SD1	Size (bp)	Position SD2	Size (bp)	Identity	Relative orientation
chr8:6909898-6919457	9,560	chr8:12608621-12617968	9,348	0.911	Inverted
chr8:6920792-6941301	20,510	chr8:12564013-12585125	21,113	0.937	Inverted
chr8:6920792-6927080	6,289	chr8:11817283-11822580	5,298	0.914	Inverted
chr8:6920792-6943606	22,815	chr8:11903577-11927642	24,066	0.936	Inverted
chr8:6920795-6926884	6,090	chr8:12600734-12604027	3,294	0.906	Inverted
chr8:6933975-6986986	53,012	chr8:12511916-12564180	52,265	0.953	Inverted
chr8:6933975-6991245	57,271	chr8:12448564-12506204	57,641	0.943	Inverted
chr8:6938243-6941301	3,059	chr8:12506037-12509055	3,019	0.926	Inverted
chr8:7017203-7092505	75,303	chr8:12511876-12586975	75,100	0.953	Direct
chr8:7060343-7069815	9,473	chr8:11903577-11912976	9,400	0.945	Direct
chr8:7069648-7092505	22,858	chr8:11905763-11929490	23,728	0.942	Direct
chr8:7084385-7092505	8,121	chr8:11817283-11824441	7,159	0.920	Direct
chr8:7084582-7092425	7,844	chr8:12600741-12605803	5,063	0.905	Direct
chr8:7107719-7115441	7,723	chr8:12313965-12321694	7,730	0.957	Inverted
chr8:7107720-7115441	7,722	chr8:12064684-12072412	7,729	0.956	Inverted
chr8:7122963-7130685	7,723	chr8:12313965-12321694	7,730	0.956	Inverted
chr8:7138207-7183224	45,018	chr8:12276250-12321694	45,445	0.956	Inverted
chr8:7138208-7225869	87,662	chr8:11986627-12072412	85,786	0.970	Inverted
chr8:7200012-7225869	25,858	chr8:12239836-12264172	24,337	0.968	Inverted
chr8:7398634-7406387	7,754	chr8:12313965-12321697	7,733	0.955	Direct
chr8:7398634-7406383	7,750	chr8:12064684-12072412	7,729	0.954	Direct
chr8:7413930-7421679	7,750	chr8:12064684-12072412	7,729	0.955	Direct
chr8:7413930-7421683	7,754	chr8:12313965-12321697	7,733	0.956	Direct
chr8:7436933-7462059	25,127	chr8:12561701-12586975	25,275	0.951	Inverted
chr8:7436933-7445048	8,116	chr8:11817283-11824441	7,159	0.921	Inverted
chr8:7436933-7459748	22,816	chr8:11905763-11929490	23,728	0.943	Inverted
chr8:7453916-7462059	8,144	chr8:12503726-12511876	8,151	0.995	Inverted
chr8:7456738-7459748	3,011	chr8:12499047-12502065	3,019	0.960	Inverted
chr8:7456738-7459748	3,011	chr8:12556963-12560029	3,067	0.926	Inverted
chr8:7459581-7462059	2,479	chr8:11910439-11912976	2,538	0.942	Inverted
chr8:7562060-7601050	38,991	chr8:12548112-12586975	38,864	0.946	Direct
chr8:7562060-7584062	22,003	chr8:12489944-12511876	21,933	0.978	Direct
chr8:7568939-7578411	9,473	chr8:11903577-11912976	9,400	0.945	Direct
chr8:7578244-7601050	22,807	chr8:11905763-11929490	23,728	0.942	Direct
chr8:7592929-7601050	8,122	chr8:11817283-11824441	7,159	0.919	Direct
chr8:7608636-7616382	7,747	chr8:12313965-12321694	7,730	0.957	Inverted
chr8:7608637-7616382	7,746	chr8:12064684-12072412	7,729	0.956	Inverted
chr8:7623927-7631678	7,752	chr8:12313965-12321697	7,733	0.955	Inverted
chr8:7623931-7631678	7,748	chr8:12064684-12072412	7,729	0.955	Inverted
chr8:7646870-7654621	7,752	chr8:12313965-12321697	7,733	0.955	Inverted
chr8:7646874-7654621	7,748	chr8:12064684-12072412	7,729	0.955	Inverted
chr8:7825885-7912022	86,138	chr8:11986627-12072412	85,786	0.971	Direct
chr8:7825885-7870364	44,480	chr8:12239836-12284637	44,802	0.979	Direct
chr8:7919569-7927319	7,751	chr8:12313965-12321697	7,733	0.955	Direct
chr8:7934925-8010143	75,219	chr8:12511876-12586975	75,100	0.954	Inverted
chr8:7934925-7943045	8,121	chr8:11817283-11824441	7,159	0.920	Inverted
chr8:7934925-7957749	22,825	chr8:11905763-11929490	23,728	0.944	Inverted
chr8:7951904-7999988	48,085	chr8:12463900-12511876	47,977	0.972	Inverted
chr8:7957582-7967066	9,485	chr8:11903577-11912976	9,400	0.948	Inverted
chr8:8001217-8134378	133,162	chr8:12321710-12461735	140,026	0.979	Inverted
chr8:8113145-8134378	21,234	chr8:12072429-12099344	26,916	0.955	Inverted

+ Evolutionary history

+ Functional effects

+ Report history

Hosted by the Comparative and Functional Genomics group at the Universitat Autònoma de Barcelona

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Description	Characterization of six large inversion polymorphisms with complex segmental duplications at the breakpoints in 27 individuals from three HapMap populations by a metaphase FISH-based assay
Method	Fluorescence in situ hybridization (FISH)

Name
Breakpoint 1	chr8:8001218-8134378	Breakpoint 2	chr8:12321711-12461735
Individuals

Description	Analysis of two inversions involving olfactory receptor-gene clusters that mediate a recurrent translocation
Method	Fluorescence in situ hybridization (FISH)

Description	Accurate prediction of inversions in the human genome from Kidd et al. 2008 fosmid paired-end mapping data using the GRIAL algorithm, and validation of some predictions by sequence analysis and PCR
Method	Paired-end mapping (PEM)

Breakpoint 1	chr8:8001218-8134378	Breakpoint 2	chr8:12321711-12461735
Assembly	hg18
Description	Breakpoints not refined due to lack of overlap of predictions in at least one breakpoint
Definition method	Default informatic definition

Breakpoint 1	chr8:8023921-8029939	Breakpoint 2	chr8:12429379-12441720
Assembly	hg18
Definition method	Default informatic definition

Ancestral allele	NA	Age	ND
Derived allele	NA	Origin	ND