Inversion Report: HsInv0712

Human Polymorphic Inversion DataBase

Inversion Report: HsInv0712

General information

Accession	HsInv0712	Region of the inversion	chr8:6909899-12617968
Status	Predicted	Prediction type	Simple
Estimated Inversion Size	4,693,244 bp	Supporting predictions	3
Inverted allele frequency	ND	Mechanism of origin	ND
Functional effect	Intergenic breakpoints	Breakpoint 1	chr8:6909899-8138867
Ancestral orientation	NA	Breakpoint 2	chr8:11817284-12617968

- Region map

+ Predictions

+ Validation and genotyping

+ Frequency

+ Breakpoints

Breakpoint 1	chr8:6909899-8138867	Breakpoint 2	chr8:11817284-12617968
Description	Breakpoints not refined due to lack of overlap of predictions in at least one breakpoint
Definition method	Default informatic definition
Mechanism of origin	ND

Flexibility

5.84

GC content

0.14

Stability

0.85

Sequence features
Segmental duplications:

Position SD1	Size (bp)	Position SD2	Size (bp)	Identity	Relative orientation
chr8:6909898-6919457	9,560	chr8:12608621-12617968	9,348	0.911	Inverted
chr8:6920792-6941301	20,510	chr8:12564013-12585125	21,113	0.937	Inverted
chr8:6920792-6927080	6,289	chr8:11817283-11822580	5,298	0.914	Inverted
chr8:6920792-6943606	22,815	chr8:11903577-11927642	24,066	0.936	Inverted
chr8:6920795-6926884	6,090	chr8:12600734-12604027	3,294	0.906	Inverted
chr8:6933975-6986986	53,012	chr8:12511916-12564180	52,265	0.953	Inverted
chr8:6933975-6991245	57,271	chr8:12448564-12506204	57,641	0.943	Inverted
chr8:6938243-6941301	3,059	chr8:12506037-12509055	3,019	0.926	Inverted
chr8:7017203-7092505	75,303	chr8:12511876-12586975	75,100	0.953	Direct
chr8:7060343-7069815	9,473	chr8:11903577-11912976	9,400	0.945	Direct
chr8:7069648-7092505	22,858	chr8:11905763-11929490	23,728	0.942	Direct
chr8:7084385-7092505	8,121	chr8:11817283-11824441	7,159	0.920	Direct
chr8:7084582-7092425	7,844	chr8:12600741-12605803	5,063	0.905	Direct
chr8:7107719-7115441	7,723	chr8:12313965-12321694	7,730	0.957	Inverted
chr8:7107720-7115441	7,722	chr8:12064684-12072412	7,729	0.956	Inverted
chr8:7122963-7130685	7,723	chr8:12313965-12321694	7,730	0.956	Inverted
chr8:7138207-7183224	45,018	chr8:12276250-12321694	45,445	0.956	Inverted
chr8:7138208-7225869	87,662	chr8:11986627-12072412	85,786	0.970	Inverted
chr8:7200012-7225869	25,858	chr8:12239836-12264172	24,337	0.968	Inverted
chr8:7398634-7406387	7,754	chr8:12313965-12321697	7,733	0.955	Direct
chr8:7398634-7406383	7,750	chr8:12064684-12072412	7,729	0.954	Direct
chr8:7413930-7421679	7,750	chr8:12064684-12072412	7,729	0.955	Direct
chr8:7413930-7421683	7,754	chr8:12313965-12321697	7,733	0.956	Direct
chr8:7436933-7459748	22,816	chr8:11905763-11929490	23,728	0.943	Inverted
chr8:7436933-7462059	25,127	chr8:12561701-12586975	25,275	0.951	Inverted
chr8:7436933-7445048	8,116	chr8:11817283-11824441	7,159	0.921	Inverted
chr8:7453916-7462059	8,144	chr8:12503726-12511876	8,151	0.995	Inverted
chr8:7456738-7459748	3,011	chr8:12556963-12560029	3,067	0.926	Inverted
chr8:7456738-7459748	3,011	chr8:12499047-12502065	3,019	0.960	Inverted
chr8:7459581-7462059	2,479	chr8:11910439-11912976	2,538	0.942	Inverted
chr8:7562060-7584062	22,003	chr8:12489944-12511876	21,933	0.978	Direct
chr8:7562060-7601050	38,991	chr8:12548112-12586975	38,864	0.946	Direct
chr8:7568939-7578411	9,473	chr8:11903577-11912976	9,400	0.945	Direct
chr8:7578244-7601050	22,807	chr8:11905763-11929490	23,728	0.942	Direct
chr8:7592929-7601050	8,122	chr8:11817283-11824441	7,159	0.919	Direct
chr8:7608636-7616382	7,747	chr8:12313965-12321694	7,730	0.957	Inverted
chr8:7608637-7616382	7,746	chr8:12064684-12072412	7,729	0.956	Inverted
chr8:7623927-7631678	7,752	chr8:12313965-12321697	7,733	0.955	Inverted
chr8:7623931-7631678	7,748	chr8:12064684-12072412	7,729	0.955	Inverted
chr8:7646870-7654621	7,752	chr8:12313965-12321697	7,733	0.955	Inverted
chr8:7646874-7654621	7,748	chr8:12064684-12072412	7,729	0.955	Inverted
chr8:7825885-7870364	44,480	chr8:12239836-12284637	44,802	0.979	Direct
chr8:7825885-7912022	86,138	chr8:11986627-12072412	85,786	0.971	Direct
chr8:7919569-7927319	7,751	chr8:12313965-12321697	7,733	0.955	Direct
chr8:7934925-7943045	8,121	chr8:11817283-11824441	7,159	0.920	Inverted
chr8:7934925-7957749	22,825	chr8:11905763-11929490	23,728	0.944	Inverted
chr8:7934925-8010143	75,219	chr8:12511876-12586975	75,100	0.954	Inverted
chr8:7951904-7999988	48,085	chr8:12463900-12511876	47,977	0.972	Inverted
chr8:7957582-7967066	9,485	chr8:11903577-11912976	9,400	0.948	Inverted
chr8:8001217-8134378	133,162	chr8:12321710-12461735	140,026	0.979	Inverted
chr8:8113145-8134378	21,234	chr8:12072429-12099344	26,916	0.955	Inverted

+ Evolutionary history

+ Functional effects

+ Report history

Hosted by the Comparative and Functional Genomics group at the Universitat Autònoma de Barcelona

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Description	Characterization of six large inversion polymorphisms with complex segmental duplications at the breakpoints in 27 individuals from three HapMap populations by a metaphase FISH-based assay
Method	Fluorescence in situ hybridization (FISH)

Name
Breakpoint 1	chr8:8001218-8134378	Breakpoint 2	chr8:12321711-12461735
Individuals

Description	Analysis of two inversions involving olfactory receptor-gene clusters that mediate a recurrent translocation
Method	Fluorescence in situ hybridization (FISH)

Description	Accurate prediction of inversions in the human genome from Kidd et al. 2008 fosmid paired-end mapping data using the GRIAL algorithm, and validation of some predictions by sequence analysis and PCR
Method	Paired-end mapping (PEM)

Name
Breakpoint 1	chr8:6909899-8134378	Breakpoint 2	chr8:11817284-12617968
Individuals

Breakpoint 1	chr8:8119230-8138867	Breakpoint 2	chr8:12314330-12336956
Assembly	hg18
Definition method	Default informatic definition

Ancestral allele	NA	Age	ND
Derived allele	NA	Origin	ND